Brainbox Initiative 宣布了一项新的网络研讨会，重点关注单脉冲和rTMS协议对健康个体运动诱发电位（MEPs）的可靠性，特邀来自德国联邦国防军大学和雷根斯堡大学的研究人员Mirja Osnabrügge和Carolina Kanig发表演讲。

经颅磁刺激（TMS）诱发的运动诱发电位（MEPs）被用作日常临床和科学实践中皮层兴奋性的神经生理标志。此外，重复应用TMS脉冲，称为重复经颅磁刺激（rTMS），通常被用作工具，以改变刺激之后一段时间内的神经活动。然而，MEPs的可靠性尚未得到明确的阐明。因此，我们的目标是确定能够产生可靠的MEP测量的协议参数，并提取和比较不同rTMS协议的重测可靠性。根据PRISMA指南，两位作者在PubMed中进行了系统性文献研究。使用标准化工具（Chipchase等人的检查清单）对符合条件的文章进行资格和方法评估。为了检验评价者之间的一致性，我们进行了 Cohen’s Kappa统计分析。结果反映了MEP的多样性，并建议在（r）TMS设置和应用中进行方法上的改进。

Time: 13:00 BST 时间：英国夏令时 13:00

(中国地区时间 20:00 - 21:00 CST)

Date: 11 May 2023 日期：2023 年 5 月 11 日

The Brainbox Initiative has announced a new webinar focusing on the reliability of motor evoked potentials (MEPs) in single pulse and rTMS protocols on healthy individuals, featuring researchers Mirja Osnabrügge and Carolina Kanig from Universität der Bundeswehr München & University of Regensburg, Germany.

Webinar Abstract

Motor evoked potentials (MEPs) elicited by transcranial magnetic stimulation (TMS) over the primary motor cortex (M1) are used as a neurophysiological marker of cortical excitability in daily clinical and scientific practice. Also the repeated application of TMS pulses, termed repetitive transcranial magnetic stimulation (rTMS) is commonly used as tool to alter neuronal activity for some time beyond stimulation. Still, the reliability of MEPs has not been clarified. Thus, our goal is to identify protocol parameters that are capable of producing a reliable MEP measurement and to extract and compare retest-reliabilities of different rTMS protocols.   According to PRISMA guidelines, two authors conducted a systematic literature research in PubMed. The articles identified as eligible were rated in terms of eligibility and methodical criteria with a standardized instrument (checklist of Chipchase et al., 2012). For inter-rater reliability we conducted Cohen’s Kappa. Results mirror the heterogeneity of MEPs and suggest methodological improvements in (r)TMS setups and applications.